Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin

I have never believed that any of those mitochondrial derived peptides (Humanin, small humanin-like peptides 1-6 and MOTS-c) actually exists and they would definitely deserve a proper takedown. This time I am just going to highlight a recent quote from Blasco et al (Blasco et al. 2018).
“However, up to date, no reliable detection of the HN peptide or transcript has been published and attempts from our lab to detect HN in human and rodent samples suggest that commercial antibodies are not specific (data not shown)."

Indeed, Humanin seems to be a Russell’s teapot within mitochondria.

References:

Blasco N, Cámara Y, Núñez E, Beà A, Barés G, Forné C, Ruíz-Meana M, Girón C, Barba I, García-Arumí E, García-Dorado D, Vázquez J, Martí R, Llovera M, Sanchis D. Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin. Redox Biol. 2018. PMID: 29502044